Theory Does pth analogs mature bones? (8 Viewers)

[HailSanta]

I did an bone age xray and even though am 16 and 1 month old my bone age is around 19. I think teriparatide might play a role in the rate my bones are maturing since my other body parts are normal ( facial, body hair and skin) can anyone confirm my theory?

 

[Skulloute]

I did an bone age xray and even though am 16 and 1 month old my bone age is around 19. I think teriparatide might play a role in the rate my bones are maturing since my other body parts are normal ( facial, body hair and skin) can anyone confirm my theory?

I am pretty sure (mb i was thinking here)

 

[paracelsus]

Don’t see how it would accelerate ageing since it’s used for osteoporosis it would want to do the opposite but it could just be your environment/genetic factors or you could be correct idk why i’m even writing this tbh i don’t have an answr

 

[Skulloute]

I did an bone age xray and even though am 16 and 1 month old my bone age is around 19. I think teriparatide might play a role in the rate my bones are maturing since my other body parts are normal ( facial, body hair and skin) can anyone confirm my theory?

No, it doesn't.

 

[Dexter]

effects of teriparatide on the skeleton are biphasic and depends entirely on dosing schedule and duration

in ur context, intermittent PTH accelerates endochondral ossification; independent of growth hormone


teriparatide acts directly on physis and the secondary ossification centers. it upregulates Indian hedgehog (Ihh) and PTH related peptide (PTHrP) signaling pathways. exogenous supraphysiologic PTH pushes chondrocytes in the GP to terminally differentiate and undergo apoptosis faster than they would naturally

normal pubertal advancement is driven by HPG axis but teriparatide acts directly on growth plate via local factors like Ihh, Runx2, Osterix so it doesnt significantly stimulate hpg axis

so yes ur skeleton is prolly maturing at a rate driven by exogenous PTH

 

[Skulloute]

effects of teriparatide on the skeleton are biphasic and depends entirely on dosing schedule and duration

in ur context, intermittent PTH accelerates endochondral ossification; independent of growth hormone


teriparatide acts directly on physis and the secondary ossification centers. it upregulates Indian hedgehog (Ihh) and PTH related peptide (PTHrP) signaling pathways. exogenous supraphysiologic PTH pushes chondrocytes in the GP to terminally differentiate and undergo apoptosis faster than they would naturally

normal pubertal advancement is driven by HPG axis but teriparatide acts directly on growth plate via local factors like Ihh, Runx2, Osterix so it doesnt significantly stimulate hpg axis

so yes ur skeleton is maturing at a rate driven by exogenous PTH

I was lowkey debating this, but

 

[dookiebootybutt59]

Indian

MY COUNTRY MENTIONED RAHHHH

 

[dookiebootybutt59]

 

[nineteen]

I did an bone age xray and even though am 16 and 1 month old my bone age is around 19. I think teriparatide might play a role in the rate my bones are maturing since my other body parts are normal ( facial, body hair and skin) can anyone confirm my theory?

teriparatide affects your bones in two different ways depending on how often and how long you use it.

taking it in short bursts speeds up endochondral ossification, and it does this without needing growth hormone.

this works directly on the growth plates and secondary ossification centers. it increases signals like Ihh and PTHrp, which control how cartilage turns into bone. when PTH levels are high from outside sources, it makes the growth plate cells mature and die faster than normally.

normally, puberty (HPG axis ) controls bone development, but teriparatide mostly bypasses that and acts locally on the growth plate through things like Ihh, Runx2, and osterix.

so basically, your bones are likely maturing faster because of external PTH, not because of normal hormonal puberty

 

[Skulloute]

teriparatide affects your bones in two different ways depending on how often and how long you use it.

taking it in short bursts speeds up endochondral ossification, and it does this without needing growth hormone.

this works directly on the growth plates and secondary ossification centers. it increases signals like Ihh and PTHrp, which control how cartilage turns into bone. when PTH levels are high from outside sources, it makes the growth plate cells mature and die faster than normally.

normally, puberty (HPG axis ) controls bone development, but teriparatide mostly bypasses that and acts locally on the growth plate through things like Ihh, Runx2, and osterix.

so basically, your bones are likely maturing faster because of external PTH, not because of normal hormonal puberty

^^^

 

[Dexter]

teriparatide affects your bones in two different ways depending on how often and how long you use it.

taking it in short bursts speeds up endochondral ossification, and it does this without needing growth hormone.

this works directly on the growth plates and secondary ossification centers. it increases signals like Ihh and PTHrp, which control how cartilage turns into bone. when PTH levels are high from outside sources, it makes the growth plate cells mature and die faster than normally.

normally, puberty (HPG axis ) controls bone development, but teriparatide mostly bypasses that and acts locally on the growth plate through things like Ihh, Runx2, and osterix.

so basically, your bones are likely maturing faster because of external PTH, not because of normal hormonal puberty

I'll stuff my cock in your mouth

 

[Skulloute]

I'll stuff my cock in your mouth

Me next?

 

[nineteen]

I'll stuff my cock in your mouth

 

[fent]

I did an bone age xray and even though am 16 and 1 month old my bone age is around 19. I think teriparatide might play a role in the rate my bones are maturing since my other body parts are normal ( facial, body hair and skin) can anyone confirm my theory?

yes they do lol