Theory NUKE ALL E2 WITH NO SIDE EFFECTS? (1 Viewer)

[birthdefect]

this is ofc for delaying bone age
the less e2 the slower bone ages, technically zeroed out e2 would be ideal but usually it cost to benefit for zeroed out e2 isnt that good
the biggest thing that niggas fear is brain development and organ development, and specifically for brain development i believe this is the solution

first of all, you 0 out all e2 with any means necessary, if that means 10mg of letrozole (likely never necessary) then so be it.

then you need to get a different estrogen into your systemic, specifcally 17a estradiol
17a estradiol is a very weak non feminising estrogen, generally being 100 times less estrogenic than the standard e2 we're familiar with (17b estradiol), and afaik 3-10 times lower binding affinity for er alpha and beta.

its a prominent candidate for anti aging therapies, as its beneficial for metabolic health, brain health, and bone health, while being weak enough to not accelerate senescence significantly

it is very neuroprotective through a novel estrogen receptor, erx. in theory, zeroed out e2(maybe even with low dose fulvestrant) then small dosing of 17a estradiol would get you to the perfect level, where brain and organ health isnt compromised but bone aging is delayed significantly

even if your plates are closed its good asf for anti aging so you should be taking it anyways tbh
lmk if this is viable, its just as easy to find as regular e2

Biomaxx VelocityAnt¹ B BastiHgH C cp_ oldfag KiriB Idkidkidc Orka orkaismylilcumslut (???)

please listen to this wonderful musik

View: https://www.youtube.com/watch?v=FqIACCH20JU

 

[Godveil Heir]

first of all AI stunting brain growth is a meme, it only apllies to mice, not humans.
https://pubmed.ncbi.nlm.nih.gov/20421333/
https://academic.oup.com/ejendo/article-abstract/163/1/149/6676682

Secondly, nuking E2 isn't the solution;
there are other mechanisms responsible for the fusion of growth plates and stopping height growth. Nuking E2 won't do

3rd

even if your plates are closed its good asf for anti aging so you should be taking it anyways tbh
lmk if this is viable, its just as easy to find as regular e2

this is pure bs
Elevated E2 is good for the skin, but there needs to be a test to balance it with testosterone, and levels should be kept within range to avoid other side effects of high estrogen.

 

[birthdefect]

first of all AI stunting brain growth is a meme, it only apllies to mice, not humans.
https://pubmed.ncbi.nlm.nih.gov/20421333/
https://academic.oup.com/ejendo/article-abstract/163/1/149/6676682

just in case tbh, earlier i had written it as "the biggest thing niggas fearmonger" rather than fear

 

[Biomaxx]

this is ofc for delaying bone age
the less e2 the slower bone ages, technically zeroed out e2 would be ideal but usually it cost to benefit for zeroed out e2 isnt that good
the biggest thing that niggas fear is brain development and organ development, and specifically for brain development i believe this is the solution

first of all, you 0 out all e2 with any means necessary, if that means 10mg of letrozole (likely never necessary) then so be it.

then you need to get a different estrogen into your systemic, specifcally 17a estradiol
17a estradiol is a very weak non feminising estrogen, generally being 100 times less estrogenic than the standard e2 we're familiar with (17b estradiol), and afaik 3-10 times lower binding affinity for er alpha and beta.

its a prominent candidate for anti aging therapies, as its beneficial for metabolic health, brain health, and bone health, while being weak enough to not accelerate senescence significantly

it is very neuroprotective through a novel estrogen receptor, erx. in theory, zeroed out e2(maybe even with low dose fulvestrant) then small dosing of 17a estradiol would get you to the perfect level, where brain and organ health isnt compromised but bone aging is delayed significantly

even if your plates are closed its good asf for anti aging so you should be taking it anyways tbh
lmk if this is viable, its just as easy to find as regular e2

Biomaxx VelocityAnt¹ B BastiHgH C cp_ oldfag KiriB Idkidkidc Orka orkaismylilcumslut (???)

please listen to this wonderful musik

View: https://www.youtube.com/watch?v=FqIACCH20JU

17a is barely studied and its nueroprotectiveness is found when regular e2 is still circulating

17a is less potent but still effects the growth plates, 100× less potent means 100x less potent in everything meaning , u would need adequate dosing to the point it has the same effect as avg e2.

I rlly like the idea but this is very likely suboptimal

 

[birthdefect]

17a is barely studied and its nueroprotectiveness is found when regular e2 is still circulating

17a is less potent but still effects the growth plates, 100× less potent means 100x less potent in everything meaning , u would need adequate dosing to the point it has the same effect as avg e2.

I rlly like the idea but this is very likely suboptimal

i dont believe its neuroprotectiveness is only possible when regular e2 is circulating, it works in low e2 states as well, and the 100x less potency is binding affinity for era and erb, not for what it really likes binding to, erx.

 

[Biomaxx]

i dont believe its neuroprotectiveness is only possible when regular e2 is circulating, it works in low e2 states as well, and the 100x less potency is binding affinity for era and erb, not for what it really likes binding to, erx.

But u stated 0 e2, pretty sure it is protective in low e2 rats tho so yh

Still tho, nothing says its less active on plates at the adequate dose for neuro

Keep going down this path tho im intrigued and think u could be onto something

 

[birthdefect]

But u stated 0 e2, pretty sure it is protective in low e2 rats tho so yh

Still tho, nothing says its less active on plates at the adequate dose for neuro

Keep going down this path tho im intrigued and think u could be onto something

theres no reason for 17a e2 to only work with circulating e2

adequate dose for neuroprotection is significantly lower than what would be needed to fuse the plates, which occurs through agonism of era's af2 domain (ideal drug would be a 2 in 1 cxxc5 - dvl inhibitor and a epiphyseal specific era af2 inhibitor, could you imagine )

 

[Biomaxx]

theres no reason for 17a e2 to only work with circulating e2

adequate dose for neuroprotection is significantly lower than what would be needed to fuse the plates, which occurs through agonism of era's af2 domain (ideal drug would be a 2 in 1 cxxc5 - dvl inhibitor and a epiphyseal specific era af2 inhibitor, could you imagine )

Yh js quoting studies

Going to bed at this moment ping me and ill reply in morning

 

[birthdefect]

Yh js quoting studies

Going to bed at this moment ping me and ill reply in morning

alr, idk what timezone you're in tbh
im in aedt

 

[birthdefect]

first of all AI stunting brain growth is a meme, it only apllies to mice, not humans.
https://pubmed.ncbi.nlm.nih.gov/20421333/
https://academic.oup.com/ejendo/article-abstract/163/1/149/6676682

Secondly, nuking E2 isn't the solution;
there are other mechanisms responsible for the fusion of growth plates and stopping height growth. Nuking E2 won't do

3rd

this is pure bs
Elevated E2 is good for the skin, but there needs to be a test to balance it with testosterone, and levels should be kept within range to avoid other side effects of high estrogen.

didnt even realise the other stuff was there

yea e2 isnt the only thing, but it is the vast majority of the cause

17a estradiol is shown to extend lifespan in male rats but not in female rats, and it does so significantly enough to make the median age of death higher in treated male rats than in untreated female rats or treated female rats. i dont see why these benefits wouldnt carry over to humans atleast a little bit, being an addition to rapamycin and epitalon

 

[Biomaxx]

alr, idk what timezone you're in tbh
im in aedt

Whatever uk is

 

[Biomaxx]

theres no reason for 17a e2 to only work with circulating e2

adequate dose for neuroprotection is significantly lower than what would be needed to fuse the plates, which occurs through agonism of era's af2 domain (ideal drug would be a 2 in 1 cxxc5 - dvl inhibitor and a epiphyseal specific era af2 inhibitor, could you imagine )

WE will be growing till 40

I see what u mean tho yh, do u have any studies i could read up on ??

 

[Circadex]

WE will be growing till 40

I see what u mean tho yh, do u have any studies i could read up on ??

I recommend this study
https://looksmax.gg/threads/circadians-grey-market-guide.19978/

 

[birthdefect]

WE will be growing till 40

I see what u mean tho yh, do u have any studies i could read up on ??

i just skimmed a few tbh ill send some later
about to have dinner

 

[birthdefect]

I recommend this study
https://looksmax.gg/threads/circadians-grey-market-guide.19978/

delete this immediately, the more sources found the harder it will be to find sources in the future

 

[Idkidkidc]

I need to look older Rather than looking younger

 

[futureslayer51]

Whatever uk is

WE are ukcels