Theory combination of ghrfs and gh (HIGH IQ NEGROS GTFIH) (7 Viewers)

[birthdefect]

just gonna make this a rapid fire thread

from: https://www.ncbi.nlm.nih.gov/books/...nging from 0.24 mg/kg/week to 0.47 mg/kg/week

this dosing is whats needed to treat short niggas
assume a patient is 60kgs for this
0.24 x 60 / 7 = ~2 mg daily dose
1mg = 3iu hgh thus the minimum STARTING DOSE is 6iu for 60kg patient. massive trvth nvke on niggas who spend like 2 months titrating up to 6iu and stopping there jfl
repeating this process for the highest dose recommended (0.47mg/kg/week) gives us ~4mg daily. 4 x 3 = 12iu daily

so just for a 60kg patient, you need minimum 6iu and max 12iu to make a significant difference

the average negro on here cannot afford 12iu daily for years on end, so a potential way to make up for this is with ghrfs and hgh combined

when i refer to ghrf (growth hormone releasing factor) im referring specifically to a ghrp+ghrh combo e.g mod-grf and ipamorelin. the shit greys dream of but does barely anything on its own. technically it can be any ghrp+ghrh but im gonna stick with mod-grf and ipamorelin just out of common familiarity.

an objective benefit of secretagogues over exogenous gh is pulsatile secretion, which we know increases localised igf1 in the growth plate chondrocytes more than the continuous exposure one would receive from hgh. while this is a benefit, ghrfs are simply not potent enough for this benefit to make up for the sheer magnitude of gh which can be delivered exogenously. why not combine them to get both benefits?

in general, we can assume exogenous gh to produce serum levels similar to the quick graph i just cooked up (not precise)

exogenous gh shuts down natural production almost entirely even at small doses so we dont need to factor that in for this

comparatively, this is the ghrf combo's assumed graph alongside the gh graph

it is known to be far smaller than exogenous gh can be (again, this is imprecise and im not using any known doses in my head, couldnt find graphs like this in studies)

if we simply add both graphs to each other, we get this result

in theory this should give you a spike in gh while simultaneously offering pseudo-pulsatile exposure, which could potentially have a more beneficial impact compared to just increasing the gh dose(although both could be done ofc)

tagging the only nigga i know here
Biomaxx

 

[birthdefect]

utterly brutal noreply pill

 

[birthdefect]

incomprehensibly brutal noreply pill

 

[Judenbänker]

incomprehensibly brutal noreply pill

maybe because you post this in the fucking questions subforum

 

[birthdefect]

maybe because you post this in the fucking questions subforum

fuck i forgot, should i repost this somewhere else?
and if so where?

 

[Biomaxx]

just gonna make this a rapid fire thread

from: https://www.ncbi.nlm.nih.gov/books/NBK598214/#:~:text=starting dose ranging from 0.24 mg/kg/week to 0.47 mg/kg/week
View attachment 20126
this dosing is whats needed to treat short niggas
assume a patient is 60kgs for this
0.24 x 60 / 7 = ~2 mg daily dose
1mg = 3iu hgh thus the minimum STARTING DOSE is 6iu for 60kg patient. massive trvth nvke on niggas who spend like 2 months titrating up to 6iu and stopping there jfl
repeating this process for the highest dose recommended (0.47mg/kg/week) gives us ~4mg daily. 4 x 3 = 12iu daily

so just for a 60kg patient, you need minimum 6iu and max 12iu to make a significant difference

the average negro on here cannot afford 12iu daily for years on end, so a potential way to make up for this is with ghrfs and hgh combined

when i refer to ghrf (growth hormone releasing factor) im referring specifically to a ghrp+ghrh combo e.g mod-grf and ipamorelin. the shit greys dream of but does barely anything on its own. technically it can be any ghrp+ghrh but im gonna stick with mod-grf and ipamorelin just out of common familiarity.

an objective benefit of secretagogues over exogenous gh is pulsatile secretion, which we know increases localised igf1 in the growth plate chondrocytes more than the continuous exposure one would receive from hgh. while this is a benefit, ghrfs are simply not potent enough for this benefit to make up for the sheer magnitude of gh which can be delivered exogenously. why not combine them to get both benefits?

in general, we can assume exogenous gh to produce serum levels similar to the quick graph i just cooked up (not precise)
View attachment 20131

exogenous gh shuts down natural production almost entirely even at small doses so we dont need to factor that in for this

comparatively, this is the ghrf combo's assumed graph alongside the gh graph
View attachment 20133
it is known to be far smaller than exogenous gh can be (again, this is imprecise and im not using any known doses in my head, couldnt find graphs like this in studies)

if we simply add both graphs to each other, we get this result
View attachment 20134
in theory this should give you a spike in gh while simultaneously offering pseudo-pulsatile exposure, which could potentially have a more beneficial impact compared to just increasing the gh dose(although both could be done ofc)

tagging the only nigga i know here
Biomaxx

This is never talled abt and its great.
Taking gh scretagogues and hgh will fix sleep, improve tissue sensitivity and keep the pituitary gland from being underestimated kinda like hcg.

Was honestly thinking of adding ibutamoren into mt cycle ar js like 30mg a day bc its cheap asf and would help but would also NUKE Any chance of me not getting type 2

 

[Biomaxx]

fuck i forgot, should i repost this somewhere else?
and if so where?

Tag an online mod or any and they'll change it

 

[birthdefect]

This is never talled abt and its great.
Taking gh scretagogues and hgh will fix sleep, improve tissue sensitivity and keep the pituitary gland from being underestimated kinda like hcg.

Was honestly thinking of adding ibutamoren into mt cycle ar js like 30mg a day bc its cheap asf and would help but would also NUKE Any chance of me not getting type 2

i wasnt really thinking about it as a way to maintain the pituitary in the way hcg maintains your peanuts. i was just wondering if we could get the benefits of hgh (massive stimulus) while also getting the benefits that pulsatile exposure has on local igf1 levels, which from memory are way more important than systemic igf1, although systemic levels are shown to compensate for a lack of local levels up to a certain extent

 

[birthdefect]

Tag an online mod or any and they'll change it

Machiavellian
please bb move thread

 

[Biomaxx]

i wasnt really thinking about it as a way to maintain the pituitary in the way hcg maintains your peanuts. i was just wondering if we could get the benefits of hgh (massive stimulus) while also getting the benefits that pulsatile exposure has on local igf1 levels, which from memory are way more important than systemic igf1, although systemic levels are shown to compensate for a lack of local levels up to a certain extent

Local igf is rather dangerous though through lack of igfpb, which you think woudnt be a problem, but it icreases risk abnormal growth and cancer cells growth. Personally id use a secragogue js for the synergy w hgh

 

[Grif]

so ibutamoren isn’t cope afterall

 

[birthdefect]

so ibutamoren isn’t cope afterall

not mk, the reason why i thought of the combination is to increase local igf1, which needs pulsatile exposure
mk is even worse at this than gh itself

 

[birthdefect]

Local igf is rather dangerous though through lack of igfpb, which you think woudnt be a problem, but it icreases risk abnormal growth and cancer cells growth. Personally id use a secragogue js for the synergy w hgh

elaborate further
for purely longitudinal growth, paracrine igf1 is more important than endocrine igf1, but systemically ofc both are necessary. my thinking was that combing secretagogues with gh itself would give you a paracrine and endocrine boost without having to spend more on gh itself and miss out on extra paracrine benefits. the cancer risk from growth factors is, in my opinion, largely overstated. growth factors arent mutagens themselves, but mitogens. they arent gonna increase cancer risk, they're just gonna seal the deal on that cancer fuckign you up if it does appear. mega dose your sunscreen on gh goyim

 

[Biomaxx]

elaborate further
for purely longitudinal growth, paracrine igf1 is more important than endocrine igf1, but systemically ofc both are necessary. my thinking was that combing secretagogues with gh itself would give you a paracrine and endocrine boost without having to spend more on gh itself and miss out on extra paracrine benefits. the cancer risk from growth factors is, in my opinion, largely overstated. growth factors arent mutagens themselves, but mitogens. they arent gonna increase cancer risk, they're just gonna seal the deal on that cancer fuckign you up if it does appear. mega dose your sunscreen on gh goyim

When hgh signal igf it gets released with igfpb which is what delivers the igf to where it need to be. Using a local injection is what causes 'free' igf, where it will float into any nearby tissue + it degrades quickly.

For longitudinal growth specifically, the driver is paracrine IGF-1 produced in the growth plate in response to GH. endocrine IGF-1 mainly permissive. GH + a secretagogue amplifies both axes: GH pulsatility increases local IGF-1 in cartilage while also raising systemic IGF-1 in a physiologic ratio, instead of spiking free IGF directly.

IGF doesn’t cause cancer. It accelerates proliferation of existing clones. Since you cannot know whether microscopic dysplasia already exists, IGFBP buffering is non-negotiable. GH-mediated signaling preserves that control; free IGF does not.

 

[carbon]

just gonna make this a rapid fire thread

from: https://www.ncbi.nlm.nih.gov/books/NBK598214/#:~:text=starting dose ranging from 0.24 mg/kg/week to 0.47 mg/kg/week
View attachment 20126
this dosing is whats needed to treat short niggas
assume a patient is 60kgs for this
0.24 x 60 / 7 = ~2 mg daily dose
1mg = 3iu hgh thus the minimum STARTING DOSE is 6iu for 60kg patient. massive trvth nvke on niggas who spend like 2 months titrating up to 6iu and stopping there jfl
repeating this process for the highest dose recommended (0.47mg/kg/week) gives us ~4mg daily. 4 x 3 = 12iu daily

so just for a 60kg patient, you need minimum 6iu and max 12iu to make a significant difference

the average negro on here cannot afford 12iu daily for years on end, so a potential way to make up for this is with ghrfs and hgh combined

when i refer to ghrf (growth hormone releasing factor) im referring specifically to a ghrp+ghrh combo e.g mod-grf and ipamorelin. the shit greys dream of but does barely anything on its own. technically it can be any ghrp+ghrh but im gonna stick with mod-grf and ipamorelin just out of common familiarity.

an objective benefit of secretagogues over exogenous gh is pulsatile secretion, which we know increases localised igf1 in the growth plate chondrocytes more than the continuous exposure one would receive from hgh. while this is a benefit, ghrfs are simply not potent enough for this benefit to make up for the sheer magnitude of gh which can be delivered exogenously. why not combine them to get both benefits?

in general, we can assume exogenous gh to produce serum levels similar to the quick graph i just cooked up (not precise)
View attachment 20131

exogenous gh shuts down natural production almost entirely even at small doses so we dont need to factor that in for this

comparatively, this is the ghrf combo's assumed graph alongside the gh graph
View attachment 20133
it is known to be far smaller than exogenous gh can be (again, this is imprecise and im not using any known doses in my head, couldnt find graphs like this in studies)

if we simply add both graphs to each other, we get this result
View attachment 20134
in theory this should give you a spike in gh while simultaneously offering pseudo-pulsatile exposure, which could potentially have a more beneficial impact compared to just increasing the gh dose(although both could be done ofc)

tagging the only nigga i know here
Biomaxx

Very intellectual

 

[Hoheit BastiHgH]

just gonna make this a rapid fire thread

from: https://www.ncbi.nlm.nih.gov/books/NBK598214/#:~:text=starting dose ranging from 0.24 mg/kg/week to 0.47 mg/kg/week
View attachment 20126
this dosing is whats needed to treat short niggas
assume a patient is 60kgs for this
0.24 x 60 / 7 = ~2 mg daily dose
1mg = 3iu hgh thus the minimum STARTING DOSE is 6iu for 60kg patient. massive trvth nvke on niggas who spend like 2 months titrating up to 6iu and stopping there jfl
repeating this process for the highest dose recommended (0.47mg/kg/week) gives us ~4mg daily. 4 x 3 = 12iu daily

so just for a 60kg patient, you need minimum 6iu and max 12iu to make a significant difference

the average negro on here cannot afford 12iu daily for years on end, so a potential way to make up for this is with ghrfs and hgh combined

when i refer to ghrf (growth hormone releasing factor) im referring specifically to a ghrp+ghrh combo e.g mod-grf and ipamorelin. the shit greys dream of but does barely anything on its own. technically it can be any ghrp+ghrh but im gonna stick with mod-grf and ipamorelin just out of common familiarity.

an objective benefit of secretagogues over exogenous gh is pulsatile secretion, which we know increases localised igf1 in the growth plate chondrocytes more than the continuous exposure one would receive from hgh. while this is a benefit, ghrfs are simply not potent enough for this benefit to make up for the sheer magnitude of gh which can be delivered exogenously. why not combine them to get both benefits?

in general, we can assume exogenous gh to produce serum levels similar to the quick graph i just cooked up (not precise)
View attachment 20131

exogenous gh shuts down natural production almost entirely even at small doses so we dont need to factor that in for this

comparatively, this is the ghrf combo's assumed graph alongside the gh graph
View attachment 20133
it is known to be far smaller than exogenous gh can be (again, this is imprecise and im not using any known doses in my head, couldnt find graphs like this in studies)

if we simply add both graphs to each other, we get this result
View attachment 20134
in theory this should give you a spike in gh while simultaneously offering pseudo-pulsatile exposure, which could potentially have a more beneficial impact compared to just increasing the gh dose(although both could be done ofc)

tagging the only nigga i know here
Biomaxx

Nice one

 

[birthdefect]

Nice one

thank you saar
posted this shit on org afterwards and got literally one reply

 

[Holy]

just gonna make this a rapid fire thread

from: https://www.ncbi.nlm.nih.gov/books/NBK598214/#:~:text=starting dose ranging from 0.24 mg/kg/week to 0.47 mg/kg/week
View attachment 20126
this dosing is whats needed to treat short niggas
assume a patient is 60kgs for this
0.24 x 60 / 7 = ~2 mg daily dose
1mg = 3iu hgh thus the minimum STARTING DOSE is 6iu for 60kg patient. massive trvth nvke on niggas who spend like 2 months titrating up to 6iu and stopping there jfl
repeating this process for the highest dose recommended (0.47mg/kg/week) gives us ~4mg daily. 4 x 3 = 12iu daily

so just for a 60kg patient, you need minimum 6iu and max 12iu to make a significant difference

the average negro on here cannot afford 12iu daily for years on end, so a potential way to make up for this is with ghrfs and hgh combined

when i refer to ghrf (growth hormone releasing factor) im referring specifically to a ghrp+ghrh combo e.g mod-grf and ipamorelin. the shit greys dream of but does barely anything on its own. technically it can be any ghrp+ghrh but im gonna stick with mod-grf and ipamorelin just out of common familiarity.

an objective benefit of secretagogues over exogenous gh is pulsatile secretion, which we know increases localised igf1 in the growth plate chondrocytes more than the continuous exposure one would receive from hgh. while this is a benefit, ghrfs are simply not potent enough for this benefit to make up for the sheer magnitude of gh which can be delivered exogenously. why not combine them to get both benefits?

in general, we can assume exogenous gh to produce serum levels similar to the quick graph i just cooked up (not precise)
View attachment 20131

exogenous gh shuts down natural production almost entirely even at small doses so we dont need to factor that in for this

comparatively, this is the ghrf combo's assumed graph alongside the gh graph
View attachment 20133
it is known to be far smaller than exogenous gh can be (again, this is imprecise and im not using any known doses in my head, couldnt find graphs like this in studies)

if we simply add both graphs to each other, we get this result
View attachment 20134
in theory this should give you a spike in gh while simultaneously offering pseudo-pulsatile exposure, which could potentially have a more beneficial impact compared to just increasing the gh dose(although both could be done ofc)

tagging the only nigga i know here
Biomaxx

dnr

 

[Mirin]

just gonna make this a rapid fire thread

from: https://www.ncbi.nlm.nih.gov/books/NBK598214/#:~:text=starting dose ranging from 0.24 mg/kg/week to 0.47 mg/kg/week
View attachment 20126
this dosing is whats needed to treat short niggas
assume a patient is 60kgs for this
0.24 x 60 / 7 = ~2 mg daily dose
1mg = 3iu hgh thus the minimum STARTING DOSE is 6iu for 60kg patient. massive trvth nvke on niggas who spend like 2 months titrating up to 6iu and stopping there jfl
repeating this process for the highest dose recommended (0.47mg/kg/week) gives us ~4mg daily. 4 x 3 = 12iu daily

so just for a 60kg patient, you need minimum 6iu and max 12iu to make a significant difference

the average negro on here cannot afford 12iu daily for years on end, so a potential way to make up for this is with ghrfs and hgh combined

when i refer to ghrf (growth hormone releasing factor) im referring specifically to a ghrp+ghrh combo e.g mod-grf and ipamorelin. the shit greys dream of but does barely anything on its own. technically it can be any ghrp+ghrh but im gonna stick with mod-grf and ipamorelin just out of common familiarity.

an objective benefit of secretagogues over exogenous gh is pulsatile secretion, which we know increases localised igf1 in the growth plate chondrocytes more than the continuous exposure one would receive from hgh. while this is a benefit, ghrfs are simply not potent enough for this benefit to make up for the sheer magnitude of gh which can be delivered exogenously. why not combine them to get both benefits?

in general, we can assume exogenous gh to produce serum levels similar to the quick graph i just cooked up (not precise)
View attachment 20131

exogenous gh shuts down natural production almost entirely even at small doses so we dont need to factor that in for this

comparatively, this is the ghrf combo's assumed graph alongside the gh graph
View attachment 20133
it is known to be far smaller than exogenous gh can be (again, this is imprecise and im not using any known doses in my head, couldnt find graphs like this in studies)

if we simply add both graphs to each other, we get this result
View attachment 20134
in theory this should give you a spike in gh while simultaneously offering pseudo-pulsatile exposure, which could potentially have a more beneficial impact compared to just increasing the gh dose(although both could be done ofc)

tagging the only nigga i know here
Biomaxx

Bump

 

[birthdefect]

Bump

bro the thread is older than time itself jfl

 

[slayless]

just gonna make this a rapid fire thread

from: https://www.ncbi.nlm.nih.gov/books/NBK598214/#:~:text=starting dose ranging from 0.24 mg/kg/week to 0.47 mg/kg/week
View attachment 20126
this dosing is whats needed to treat short niggas
assume a patient is 60kgs for this
0.24 x 60 / 7 = ~2 mg daily dose
1mg = 3iu hgh thus the minimum STARTING DOSE is 6iu for 60kg patient. massive trvth nvke on niggas who spend like 2 months titrating up to 6iu and stopping there jfl
repeating this process for the highest dose recommended (0.47mg/kg/week) gives us ~4mg daily. 4 x 3 = 12iu daily

so just for a 60kg patient, you need minimum 6iu and max 12iu to make a significant difference

the average negro on here cannot afford 12iu daily for years on end, so a potential way to make up for this is with ghrfs and hgh combined

when i refer to ghrf (growth hormone releasing factor) im referring specifically to a ghrp+ghrh combo e.g mod-grf and ipamorelin. the shit greys dream of but does barely anything on its own. technically it can be any ghrp+ghrh but im gonna stick with mod-grf and ipamorelin just out of common familiarity.

an objective benefit of secretagogues over exogenous gh is pulsatile secretion, which we know increases localised igf1 in the growth plate chondrocytes more than the continuous exposure one would receive from hgh. while this is a benefit, ghrfs are simply not potent enough for this benefit to make up for the sheer magnitude of gh which can be delivered exogenously. why not combine them to get both benefits?

in general, we can assume exogenous gh to produce serum levels similar to the quick graph i just cooked up (not precise)
View attachment 20131

exogenous gh shuts down natural production almost entirely even at small doses so we dont need to factor that in for this

comparatively, this is the ghrf combo's assumed graph alongside the gh graph
View attachment 20133
it is known to be far smaller than exogenous gh can be (again, this is imprecise and im not using any known doses in my head, couldnt find graphs like this in studies)

if we simply add both graphs to each other, we get this result
View attachment 20134
in theory this should give you a spike in gh while simultaneously offering pseudo-pulsatile exposure, which could potentially have a more beneficial impact compared to just increasing the gh dose(although both could be done ofc)

tagging the only nigga i know here
Biomaxx

yo am i tripping or are u that nigga that i always used to see on org in my lurking era. if yes .gg is genuinely becoming the new .org. Mirin thread. and also question for you: have you already pinned any of this?

 

[carbon]

I remember reading this when it was first posted. I want to try it along with AI. Has anybody tried it before?

 

[birthdefect]

yo am i tripping or are u that nigga that i always used to see on org in my lurking era. if yes .gg is genuinely becoming the new .org. Mirin thread. and also question for you: have you already pinned any of this?

gg isnt the new org yet i just migrated
and no, i havent tried this

I remember reading this when it was first posted. I want to try it along with AI. Has anybody tried it before?

not that i know of, fairly expensive
and you couldnt even test the benefit since the goal of this is to increase paracrine igf1, and that cant be measured

 

[slayless]

gg isnt the new org yet i just migrated
and no, i havent tried this

not that i know of, fairly expensive
and you couldnt even test the benefit since the goal of this is to increase paracrine igf1, and that cant be measured

you think other pslers from org are gonna migrate too?

 

[birthdefect]

you think other pslers from org are gonna migrate too?

yes, they'll trickle in albeit slowly
very strange feeling to be the person who's posts are read by a lurker
im like your zagro or sachlichkeit or 7evenvox22 or stacyslayer
how marvellous

 

[JackthehammerJack]

yes, they'll trickle in albeit slowly
very strange feeling to be the person who's posts are read by a lurker
im like your zagro or sachlichkeit or 7evenvox22 or stacyslayer
how marvellous

 

[atrophicpyra]

just gonna make this a rapid fire thread

from: https://www.ncbi.nlm.nih.gov/books/NBK598214/#:~:text=starting dose ranging from 0.24 mg/kg/week to 0.47 mg/kg/week
View attachment 20126
this dosing is whats needed to treat short niggas
assume a patient is 60kgs for this
0.24 x 60 / 7 = ~2 mg daily dose
1mg = 3iu hgh thus the minimum STARTING DOSE is 6iu for 60kg patient. massive trvth nvke on niggas who spend like 2 months titrating up to 6iu and stopping there jfl
repeating this process for the highest dose recommended (0.47mg/kg/week) gives us ~4mg daily. 4 x 3 = 12iu daily

so just for a 60kg patient, you need minimum 6iu and max 12iu to make a significant difference

the average negro on here cannot afford 12iu daily for years on end, so a potential way to make up for this is with ghrfs and hgh combined

when i refer to ghrf (growth hormone releasing factor) im referring specifically to a ghrp+ghrh combo e.g mod-grf and ipamorelin. the shit greys dream of but does barely anything on its own. technically it can be any ghrp+ghrh but im gonna stick with mod-grf and ipamorelin just out of common familiarity.

an objective benefit of secretagogues over exogenous gh is pulsatile secretion, which we know increases localised igf1 in the growth plate chondrocytes more than the continuous exposure one would receive from hgh. while this is a benefit, ghrfs are simply not potent enough for this benefit to make up for the sheer magnitude of gh which can be delivered exogenously. why not combine them to get both benefits?

in general, we can assume exogenous gh to produce serum levels similar to the quick graph i just cooked up (not precise)
View attachment 20131

exogenous gh shuts down natural production almost entirely even at small doses so we dont need to factor that in for this

comparatively, this is the ghrf combo's assumed graph alongside the gh graph
View attachment 20133
it is known to be far smaller than exogenous gh can be (again, this is imprecise and im not using any known doses in my head, couldnt find graphs like this in studies)

if we simply add both graphs to each other, we get this result
View attachment 20134
in theory this should give you a spike in gh while simultaneously offering pseudo-pulsatile exposure, which could potentially have a more beneficial impact compared to just increasing the gh dose(although both could be done ofc)

tagging the only nigga i know here
Biomaxx

wouldnt this just desensitize gh receptors?

 

[birthdefect]

wouldnt this just desensitize gh receptors?

i mean gh receptor desensitisation doesnt occur when its pulsatile
since this pulsatile in a way perhaps it wont

 

[birthdefect]

i mean gh receptor desensitisation doesnt occur when its pulsatile
since this pulsatile in a way perhaps it wont

since this is pulsatile in a way perhaps desensitisation wont occur

 

[atrophicpyra]

since this is pulsatile in a way perhaps desensitisation wont occur

i mean gh receptor desensitisation doesnt occur when its pulsatile
since this pulsatile in a way perhaps it wont

gng i dont see A SINGLE second where gh isnt getting secreted in that graph

 

[birthdefect]

gng i dont see A SINGLE second where gh isnt getting secreted in that graph

by pulsatile i just mean up and down
not any moments when gh doesnt get secreted

 

[zentro]

yes, they'll trickle in albeit slowly
very strange feeling to be the person who's posts are read by a lurker
im like your zagro or sachlichkeit or 7evenvox22 or stacyslayer
how marvellous

7evenvox22 mentioned

 

[Syna]

fent

 

[fent]

just gonna make this a rapid fire thread

from: https://www.ncbi.nlm.nih.gov/books/...nging from 0.24 mg/kg/week to 0.47 mg/kg/week
View attachment 20126
this dosing is whats needed to treat short niggas
assume a patient is 60kgs for this
0.24 x 60 / 7 = ~2 mg daily dose
1mg = 3iu hgh thus the minimum STARTING DOSE is 6iu for 60kg patient. massive trvth nvke on niggas who spend like 2 months titrating up to 6iu and stopping there jfl
repeating this process for the highest dose recommended (0.47mg/kg/week) gives us ~4mg daily. 4 x 3 = 12iu daily

so just for a 60kg patient, you need minimum 6iu and max 12iu to make a significant difference

the average negro on here cannot afford 12iu daily for years on end, so a potential way to make up for this is with ghrfs and hgh combined

when i refer to ghrf (growth hormone releasing factor) im referring specifically to a ghrp+ghrh combo e.g mod-grf and ipamorelin. the shit greys dream of but does barely anything on its own. technically it can be any ghrp+ghrh but im gonna stick with mod-grf and ipamorelin just out of common familiarity.

an objective benefit of secretagogues over exogenous gh is pulsatile secretion, which we know increases localised igf1 in the growth plate chondrocytes more than the continuous exposure one would receive from hgh. while this is a benefit, ghrfs are simply not potent enough for this benefit to make up for the sheer magnitude of gh which can be delivered exogenously. why not combine them to get both benefits?

in general, we can assume exogenous gh to produce serum levels similar to the quick graph i just cooked up (not precise)
View attachment 20131

exogenous gh shuts down natural production almost entirely even at small doses so we dont need to factor that in for this

comparatively, this is the ghrf combo's assumed graph alongside the gh graph
View attachment 20133
it is known to be far smaller than exogenous gh can be (again, this is imprecise and im not using any known doses in my head, couldnt find graphs like this in studies)

if we simply add both graphs to each other, we get this result
View attachment 20134
in theory this should give you a spike in gh while simultaneously offering pseudo-pulsatile exposure, which could potentially have a more beneficial impact compared to just increasing the gh dose(although both could be done ofc)

tagging the only nigga i know here
Biomaxx

fent

ngl i could prob do a super in depth thread compared to this but its intresting stuff

 

[birthdefect]

ngl i could prob do a super in depth thread compared to this but its intresting stuff

if you make one tag me in it
i had an epiphany about this topic at night a while ago and forget it but im pretty sure it was some pretty crazy stuff

shit i thought i posted this already, was looking at my post and realised it couldve had something to do with pinning double your gh dose eod instead of standard dose everyday
ill make a graph on it rn