Guide Dihydrotestosterone: Why it DOES NOT affect your JAW (Part 2) (7 Viewers)

[Mandy]

Man I fucking love this

 

[Dexter]

Man I fucking love this

ty biggest fish

 

[Daker]

sorry for being this late, mirin the brutal evisceration of the DHT coper, they deserved to get raped by the norwood reaper for being this retarded

 

[Mirin]

Will read when im not abt to pass out

 

[Dexter]

sorry for being this late, mirin the brutal evisceration of the DHT coper, they deserved to get raped by the norwood reaper for being this retarded

ty brooke

 

[Dexter]

bump tbh wtf should i post next

 

[Nardicus]

Suicide Fuel for DHTcels reading this

Mirin hard
2.5mg of Dut till death

 

[carbon]

Prob most knowledgeable guy here. Still sad it’s over between us

 

[Dexter]

Prob most knowledgeable guy here. Still sad it’s over between us

nigga thinks he's in a romance novel

 

[tomahawk]

https://pubmed.ncbi.nlm.nih.gov/8853853/

 

[FoidSlayer]

https://pubmed.ncbi.nlm.nih.gov/8853853/

In rats?

 

[tomahawk]

In rats?

Yes, in rats.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5651475/

 

[Dexter]

Yes, in rats.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5651475/

MC3T3-E1 cells are murine calvarial osteoblasts, they come from mouse skull not a human jaw. And also murine osteoblasts express 5AR differently than us.

it proves osteoblasts [UWSL]CAN respond to DHT if DHT is PRESENT, but it doesn't say whether DHT is present in human jaw during fetal development. [/UWSL][UWSL]human mandibular osteoblasts in vivo arent exposed to this conc (0.1ng/ml) because they dont express 5AR.[/UWSL]


[UWSL]and from what ive read from that article, the researchers added exogenous DHT directly to the culture medium at 0.1ng/ml. this bypasses the entire question of whether human mandibular osteoblasts produce DHT from T.[/UWSL]

[UWSL] "could be the in vitro basis for the efficacy of 5α-DHT in the treatment of androgen-deficient male osteoporosis."[/UWSL]
[UWSL]osteoporosis is a condition of systemic androgenic deficiency. in a man with no T (hypogonadal), both T and DHT are low. giving exo DHT provides SOME androgenic signal to bone, but this in a way is just a rescue.[/UWSL]

 

[Alyx]

Good thread.

 

[medialcathus]

dnr just make me htn+ plz. really nice formatting tho love it