Serious Lookism secrets chemical part 1: 11-keto DHT (1 Viewer)

[𝐇𝐚𝐥𝐜𝐲𝐬𝐭𝐢𝐬.]

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Oooooooo the admin himself is angry Grilldaddy83 Zynx truestcel

 

[PrettyBoyMaxxing]

You are not allowed to post threads from this forum on other forums, nor are you allowed to post threads from other forums on this forum, I thought that was clear.

Oh, didn’t know, won’t happen again

 

[𝐇𝐚𝐥𝐜𝐲𝐬𝐭𝐢𝐬.]

Oh, didn’t know, won’t happen again

U are shaking right now

 

[PrettyBoyMaxxing]

U are shaking right now

What

 

[Kaligula567]

Oh, didn’t know, won’t happen again

i didn't know that either, it's ok just don't do it again

 

[𝐇𝐚𝐥𝐜𝐲𝐬𝐭𝐢𝐬.]

i didn't know that either, it's ok just don't do it again

Bro is not the admin

 

[Kaligula567]

Bro is not the admin

i'm a mod

 

[𝐇𝐚𝐥𝐜𝐲𝐬𝐭𝐢𝐬.]

i'm a mod

Okay and what tf should I do about it

 

[Kaligula567]

Okay and what tf should I do about it

you said your gonna play cricker, stop wasting my time kid

 

[𝐇𝐚𝐥𝐜𝐲𝐬𝐭𝐢𝐬.]

you said your gonna play cricker, stop wasting my time kid

Now u say kid yesterday u said 20 years old on meth

 

[𝐇𝐚𝐥𝐜𝐲𝐬𝐭𝐢𝐬.]

you said your gonna play cricker, stop wasting my time kid

I actually want to stop this war between me and u

 

[Kaligula567]

Now u say kid yesterday u said 20 years old on meth

is it my fault that you told me like 3 difirent ages + the meth thing and the psychosis your in is general knowledge

 

[Kaligula567]

0

 

[adolfbrax]

once this forum has more members it will be better

its just a lil inactive rn

.org is ran by jews, fuck them

.org sucks just pedos

 

[Admincel]

bump

 

[ahavik]

most info is gathered from .net or my buddy ex cr:

Preface

I will be writing a series of threads showcasing unknown but useful chemicals.

Abstract

- 11-KDHT is a powerful androgen that demonstrates strong agonist activity on the androgen receptor (AR). It is also capable of regulating a wider range of AR-dependent proteins compared to DHT.

- A key advantage of 11-KDHT and 11-Ketotestosterone (11KT) is their slower metabolic breakdown, resulting in a significantly longer half-life than DHT and Testosterone (T). The half-life of 11-KDHT is approximately 36 hours. Studies show that while DHT is eliminated within 48 hours, over one-fifth (21%) of 11-KDHT remains in the body after 72 hours.

- Both 11KT and 11KDHT bind to the androgen receptor with an affinity comparable to T and DHT. They function as full agonists, effectively activating the AR to induce gene expression and stimulate the proliferation of androgen-dependent cells.


11-KDHT is critically important in the progression of castration-resistant prostate cancer. Interestingly, patients with this condition often present with low levels of prolactin.

Given that 11-KDHT is as potent as DHT-- a known suppressor of prolactin so it may offer a unique benefit. Its prolonged duration of action could allow for less frequent dosing while effectively managing prolactin levels. This makes it a potential substitute for other steroids that can raise prolactin. Furthermore, by mitigating prolactin's effects, it may also enhance sexual function by reducing the refractory period.


Moreover, 11-KDHT can also be used as an aromatase inhibitor with longer inter-dose intervals. Due to it being similar to DHT for its anti-estrogenic properties.
This may be useful to Zynx or other pubertycels to keep their plates open while promoting cell proliferation and skipping the horrendous side effects of AIs like aromasin or letrozole.



11-KT and 11-KDHT are also non-aromatizable, meaning that they won't get converted into estrogen, meaning they have no gyno side effects like other steroids.

To add, there are also anecdotal evidence in DHT and 11-KDHT elimating bloat and promoting a "dry" look.

Finally, 11-KT has anti-cortisol properties, which promotes "alpha" personality and inhibition, less stress, and better motivation. And so does its anti-prolactin properties.[5] 11-KDHT also has this property


TLDR by @ex.chr on .net:

11KDHT and 11KT do the following:
-Increase NT
-lower inhibition
-Increase aggression
-lower stress
-enhance sexual experience
-decrease refractory period (time it take for a male to recover after orgasm.)
-Decrease estrogen
-Build muscle
-Burn fat
-Increase height in open platecels
-doesn't need AI
-Increase energy
-Eliminate bloat
-Decrease fatigue



in-depth detail for autists:



Biosynthesis from the precursor 11OHA4:


View attachment 691



Binding of DHT, T, 11KDHT and 11KT to the human AR (A) and transactivation via an ARE (B and C).


View attachment 692



Regulation of AR-regulated proteins by DHT, 11KDHT, T and 11KT in VCaP cells:



View attachment 693


Metabolism:



View attachment 694



sources:

https://www.researchgate.net/public...tent_Androgens_Which_Can_No_Longer_Be_Ignored
https://www.ncbi.nlm.nih.gov/pubmed/2775814
https://www.ncbi.nlm.nih.gov/pubmed/30763940
https://www.ncbi.nlm.nih.gov/pubmed/6645492
https://www.researchgate.net/public...tent_Androgens_Which_Can_No_Longer_Be_Ignored
https://academic.oup.com/jcem/article/101/10/3582/2764896
http://press.endocrine.org/doi/10.1210/endo-meetings.2015.NRSHA.6.SAT-276

Administrator Zynx nettspend Jean

dnr

 

[birthdefect]

most info is gathered from .net or my buddy ex cr:

Preface

I will be writing a series of threads showcasing unknown but useful chemicals.

Abstract

- 11-KDHT is a powerful androgen that demonstrates strong agonist activity on the androgen receptor (AR). It is also capable of regulating a wider range of AR-dependent proteins compared to DHT.

- A key advantage of 11-KDHT and 11-Ketotestosterone (11KT) is their slower metabolic breakdown, resulting in a significantly longer half-life than DHT and Testosterone (T). The half-life of 11-KDHT is approximately 36 hours. Studies show that while DHT is eliminated within 48 hours, over one-fifth (21%) of 11-KDHT remains in the body after 72 hours.

- Both 11KT and 11KDHT bind to the androgen receptor with an affinity comparable to T and DHT. They function as full agonists, effectively activating the AR to induce gene expression and stimulate the proliferation of androgen-dependent cells.


11-KDHT is critically important in the progression of castration-resistant prostate cancer. Interestingly, patients with this condition often present with low levels of prolactin.

Given that 11-KDHT is as potent as DHT-- a known suppressor of prolactin so it may offer a unique benefit. Its prolonged duration of action could allow for less frequent dosing while effectively managing prolactin levels. This makes it a potential substitute for other steroids that can raise prolactin. Furthermore, by mitigating prolactin's effects, it may also enhance sexual function by reducing the refractory period.


Moreover, 11-KDHT can also be used as an aromatase inhibitor with longer inter-dose intervals. Due to it being similar to DHT for its anti-estrogenic properties.
This may be useful to Zynx or other pubertycels to keep their plates open while promoting cell proliferation and skipping the horrendous side effects of AIs like aromasin or letrozole.



11-KT and 11-KDHT are also non-aromatizable, meaning that they won't get converted into estrogen, meaning they have no gyno side effects like other steroids.

To add, there are also anecdotal evidence in DHT and 11-KDHT elimating bloat and promoting a "dry" look.

Finally, 11-KT has anti-cortisol properties, which promotes "alpha" personality and inhibition, less stress, and better motivation. And so does its anti-prolactin properties.[5] 11-KDHT also has this property


TLDR by @ex.chr on .net:

11KDHT and 11KT do the following:
-Increase NT
-lower inhibition
-Increase aggression
-lower stress
-enhance sexual experience
-decrease refractory period (time it take for a male to recover after orgasm.)
-Decrease estrogen
-Build muscle
-Burn fat
-Increase height in open platecels
-doesn't need AI
-Increase energy
-Eliminate bloat
-Decrease fatigue



in-depth detail for autists:



Biosynthesis from the precursor 11OHA4:


View attachment 691



Binding of DHT, T, 11KDHT and 11KT to the human AR (A) and transactivation via an ARE (B and C).


View attachment 692



Regulation of AR-regulated proteins by DHT, 11KDHT, T and 11KT in VCaP cells:



View attachment 693


Metabolism:



View attachment 694



sources:

https://www.researchgate.net/public...tent_Androgens_Which_Can_No_Longer_Be_Ignored
https://www.ncbi.nlm.nih.gov/pubmed/2775814
https://www.ncbi.nlm.nih.gov/pubmed/30763940
https://www.ncbi.nlm.nih.gov/pubmed/6645492
https://www.researchgate.net/public...tent_Androgens_Which_Can_No_Longer_Be_Ignored
https://academic.oup.com/jcem/article/101/10/3582/2764896
http://press.endocrine.org/doi/10.1210/endo-meetings.2015.NRSHA.6.SAT-276

Administrator Zynx nettspend Jean

good thread but something people over look is that 11 oxygenated compounds actually can be aromatised into 11 oxygenated estrogens. 11kt is aromatisable, 11kdht isnt

You are not allowed to post threads from this forum on other forums, nor are you allowed to post threads from other forums on this forum, I thought that was clear.

is it halal if its your own post

 

[Biomaxx]

good thread but something people over look is that 11 oxygenated compounds actually can be aromatised into 11 oxygenated estrogens. 11kt is aromatisable, 11kdht isnt

is it halal if its your own post

How did u even find this, whole thread is a straight graveyard

 

[birthdefect]

How did u even find this, whole thread is a straight graveyard

i sensed common misinformation and i had to correct it to save the masses