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Why KY-19382 shoudnt be used (height) (3 Viewers)

Why KY-19382 shoudnt be used (height)
  • Thread starter Biomaxx
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fent

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Biomaxx

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birthdefect

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  • #18
My solution for this would be using a pure cxxc5 inhibitor, some ive found so far are A334 and Ce123 or whatever cant remmeber the name
if you look very very very closely you'll see i actually mentioned this
1780465746843.png

btw those straight underlines i drew with a mouse cursor, no line tool
mirin?
I get scared everytime you comment on my posts

The gsk3b inhibiton is what causes the b cantenin surge

Obvisuly its not gonna be a massive issue but imo nothing in a hieght stack accelerate differentiation, even a little
if you dont wanna accelerate differentiation you would also remove all androgens, but ofc you dont because like wnt upreg (up to a certain point) its beneficial
its only bad if you over do it
 

Biomaxx

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  • #19
if you look very very very closely you'll see i actually mentioned this
View attachment 53703
btw those straight underlines i drew with a mouse cursor, no line tool
mirin?

if you dont wanna accelerate differentiation you would also remove all androgens, but ofc you dont because like wnt upreg (up to a certain point) its beneficial
its only bad if you over do it
Mirin that steady hands

I think any amount of ky would have the same effect tho, sort of like a differentiation:proliferation and growth ratio ig


Sorry I did not see ur original post I dont think
 

Biomaxx

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  • #20
if you look very very very closely you'll see i actually mentioned this
View attachment 53703
btw those straight underlines i drew with a mouse cursor, no line tool
mirin?

if you dont wanna accelerate differentiation you would also remove all androgens, but ofc you dont because like wnt upreg (up to a certain point) its beneficial
its only bad if you over do it
I did see ur comment think i js dnred most of it
 

Scorpion

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  • #21

fent

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  • #22
if you look very very very closely you'll see i actually mentioned this
View attachment 53703
btw those straight underlines i drew with a mouse cursor, no line tool
mirin?

if you dont wanna accelerate differentiation you would also remove all androgens, but ofc you dont because like wnt upreg (up to a certain point) its beneficial
its only bad if you over do it
alright so, did some more research
using a334 inhibiting CXXC5-DVL does not cause premature fusion because CXXC5 acts as an off switch that targets all zones of the growth plate concurrently.
for premature fusion to occur the rate of terminal hypertrophy needs to exhaust the supply of profilerating cells. when wnt/b is restored or increased it increases profileration
 

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  • #23

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