Mogs Romosozuma (advanced) (1 Viewer)

[birthdefect]

Only problem with things for osteoporosis is that they increase bone mass and not bone remodeling could be good if you were boneless but most people require bone remodeling

upregulating bone remodelling i imagine would be done by upregulating both resorption and formation
perhaps higher doses of pth analogues (past 80mcg to escape that net anabolic window) and then somethign to upregulate bone formation (romosozumab, hgh, whatever). that should make bones more plastic so they would respond better to mechanical forces but who really knows fr

 

[Dillon]

upregulating bone remodelling i imagine would be done by upregulating both resorption and formation
perhaps higher doses of pth analogues (past 80mcg to escape that net anabolic window) and then somethign to upregulate bone formation (romosozumab, hgh, whatever). that should make bones more plastic so they would respond better to mechanical forces but who really knows fr

Could be really good or just not work theres no real studies about bone remodeling on PTH analogues

 

[birthdefect]

Could be really good or just not work theres no real studies about bone remodeling on PTH analogues

i dont see why it wouldnt work at all
i mentioned pth analogues because they only have a net gain on bone formation within a certain "anabolic" window. this is why doses are always 20mcg for teriparatide and 80mcg for abaloparatide. going past it promotes net bone loss, as in resorption. each of the drugs mentioned do their respective jobs properly, and the reasoning behind high bone resorption and high bone formation being simultaneously necessary is correct.

only concern is if the pth analogue (which would have to be administered far more often than just once a day) outpaces the formation from romosozumab, leading to osteoporosis. theres prob better ways to upregulate both formation and resorption

 

[Biomaxx]

i dont see why it wouldnt work at all
i mentioned pth analogues because they only have a net gain on bone formation within a certain "anabolic" window. this is why doses are always 20mcg for teriparatide and 80mcg for abaloparatide. going past it promotes net bone loss, as in resorption. each of the drugs mentioned do their respective jobs properly, and the reasoning behind high bone resorption and high bone formation being simultaneously necessary is correct.

only concern is if the pth analogue (which would have to be administered far more often than just once a day) outpaces the formation from romosozumab, leading to osteoporosis. theres prob better ways to upregulate both formation and resorption

Follow me back ur high iq

 

[birthdefect]

Follow me back ur high iq

alr, you on org as well?

 

[Biomaxx]

alr, you on org as well?

Never joined and I refuse to be part of the newgen waves. On .com but thats a secret

 

[birthdefect]

Never joined and I refuse to be part of the newgen waves. On .com but thats a secret

i understand. i made the mistake of lurking way before the newgen wave and making an account during it, dont even have a tiktok account
no way to seperate myself from retarded tiktok users

 

[HailSanta]

What is romosozumab, and how could it potentially induce bone growth and make you taller?
Romosozumab is a sclerostin inhibitor that activates the Wnt signalling pathway for bone formation. This is an FDA approved treatment for osteoporosis, rapidly growing bone.
Romosozumab has a short, high-gain anabolic window—mechanistically and clinically. That is why it's the front-end agent in a stack meant to form and subsequently preserve new bone after mechanical stimulus. For our purposes, we’re talking about jumping, bone-smashing, LSJL, or banded sleeping.
Transition to alendronate or denosumab after romosozumab to preserve new geometry. In a Phase 1b study, trabecular bone mass, density, and stiffness (i.e., anti-resorption) was up-regulated by 26.9% in men after three months of treatment.
This dual action of up-regulating bone formation while simultaneously decreasing resorption makes it incredibly unique when compared to other agents like PTH analogues. Heightmaxing and bone growth protocols are always experimental, but this compound might be the key puzzle piece in the stack.

It costs 3.3k for a yearly cycle

 

[HailSanta]

What is romosozumab, and how could it potentially induce bone growth and make you taller?
Romosozumab is a sclerostin inhibitor that activates the Wnt signalling pathway for bone formation. This is an FDA approved treatment for osteoporosis, rapidly growing bone.
Romosozumab has a short, high-gain anabolic window—mechanistically and clinically. That is why it's the front-end agent in a stack meant to form and subsequently preserve new bone after mechanical stimulus. For our purposes, we’re talking about jumping, bone-smashing, LSJL, or banded sleeping.
Transition to alendronate or denosumab after romosozumab to preserve new geometry. In a Phase 1b study, trabecular bone mass, density, and stiffness (i.e., anti-resorption) was up-regulated by 26.9% in men after three months of treatment.
This dual action of up-regulating bone formation while simultaneously decreasing resorption makes it incredibly unique when compared to other agents like PTH analogues. Heightmaxing and bone growth protocols are always experimental, but this compound might be the key puzzle piece in the stack.

Holy cope

 

[Orka]

What is romosozumab, and how could it potentially induce bone growth and make you taller?
Romosozumab is a sclerostin inhibitor that activates the Wnt signalling pathway for bone formation. This is an FDA approved treatment for osteoporosis, rapidly growing bone.
Romosozumab has a short, high-gain anabolic window—mechanistically and clinically. That is why it's the front-end agent in a stack meant to form and subsequently preserve new bone after mechanical stimulus. For our purposes, we’re talking about jumping, bone-smashing, LSJL, or banded sleeping.
Transition to alendronate or denosumab after romosozumab to preserve new geometry. In a Phase 1b study, trabecular bone mass, density, and stiffness (i.e., anti-resorption) was up-regulated by 26.9% in men after three months of treatment.
This dual action of up-regulating bone formation while simultaneously decreasing resorption makes it incredibly unique when compared to other agents like PTH analogues. Heightmaxing and bone growth protocols are always experimental, but this compound might be the key puzzle piece in the stack.

I was listening to your tiktok about it and noticed that this thread was literally a word-for-word copy of the tiktok

then I realized that the tiktok video was made by YOU, kek.

Anyway, why would this do anything more than increase BMD? An increase in BMD isn't directly linked to a physical visible change in bonemass

 

[birthdefect]

I was listening to your tiktok about it and noticed that this thread was literally a word-for-word copy of the tiktok

then I realized that the tiktok video was made by YOU, kek.

Anyway, why would this do anything more than increase BMD? An increase in BMD isn't directly linked to a physical visible change in bonemass

i agree with you tbh, i dont believe really any anabolic agent out their can noticeably increase cortical thickness in the face without using it for years upon years. women actually do get bone masculinisation when using androgens, but thats simply because their androgen receptors are far less saturated than ours. romosozumab (and afaik pth/pthrp analogues for that matter) has been shown to increase cortical thickness(fairly significantly), specifically in load bearing bones such as the legs, hips, spine, and radius. i imagine that romosozumab combined with hard chewing for years and years would likely result in a significant increase in cortical thickness, but i have no idea at what point it would become visible, if it would even be aesthetic, and how much the masseter would grow. no point in doing all that when you have giant ass masseters that you need to use botox on. filler is the way tbh

and for longitudinal growth i think i had mentioned it in this thread why it wouldnt work but if i havent thats my bad